Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic memory. Aerobic fitness is positively correlated with total hippocampal volume, a heavily studied memory-critical region within the MTL. More sedentary non-demented individuals have less MTL thickness, spending all day in your desk chair — were linked to changes in a part of the adult brain that’s critical for memory.
Specifically, the new study linked sedentary behavior to thinning of the medial temporal lobe, a brain region involved in the formation of new memories. Sitting for extended periods of time was closely associated with thinning in the medial temporal lobe, regardless of one’s physical activity level. In other words, the study suggests that “sedentary behavior is a significant predictor of thinning of the [medial temporal lobe] and that physical activity, even at high levels, is insufficient to offset the harmful effects of sitting for extended periods,” the researchers said in the statement.
Action Item: “reducing sedentary behavior may be a possible target for interventions designed to improve brain health in people at risk for Alzheimer’s disease.”
Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults.
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